Lab members in bold. * indicates corresponding author.
Independent Research
2026
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Xiong, W., Ser, Z., Sobota, R.M., Lin, Z.* (2026) Global profiling of nascent chain interactors reveals TRIM25 as a co-translational E3 ubiquitin ligase. Mol Cell. 10.1016/j.molcel.2026.02.007
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​Yang, B., Li, B., Zhu, Y.*, Zhao, M., Cheng, Y., Zhao, X., Teoh En-Jie, D., Wang, Y., Zhang, M., Tang, X., Jin, S., Sun, Y., Zhang, X., Xue, B., Yan, J., Wu, G., Lin, Z., Luo, M., Yu, H., Zhang, L., Chen, X.*, and Ni, Q.* (2026). Rational design of rigid mRNA folding architecture to enhance intracellular processing and protein production. Nat Nanotechnol. 10.1038/s41565-025-02114-9.
2024
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Batiuk, A., Hopfler, M., Almeida, A.C., Teoh En-Jie, D., Vadas, O., Vartholomaiou, E., Hegde, R.S., Lin, Z.*, and Gasic, I.* (2024). Soluble alphabeta-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay. Nat Commun. 10.1038/s41467-024-54036-0.
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Li, J., and Lin, Z.* (2024). An integrated approach using proximity labelling and chemical crosslinking to probe in situ host-virus protein-protein interactions. QRB Discovery. e11. 10.1017/qrd.2024.19.
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​Lee, B.W.L., Chuah, Y.H., Yoon, J., Grinchuk, O.V., Liang, Y., Hirpara, J.L., Shen, Y., Wang, L.C., Lim, Y.T., Zhao, T., Sobota, R.M., Yeo, T.T., Wong, A.L.A., Teo, K., Nga, V.D.W., Tan, B.W.Q., Suda, T., Toh, T.B., Pervaiz, S., Lin, Z., and Ong, D.S.T.* (2024). METTL8 links mt-tRNA m(3)C modification to the HIF1alpha/RTK/Akt axis to sustain GBM stemness and tumorigenicity. Cell Death Dis. 10.1038/s41419-024-06718-2.
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Rozario, P., Pinilla, M., Gorse, L., Vind, A.C., Robinson, K.S., Toh, G.A., Firdaus, M.J., Martinez, J.F., Kerk, S.K., Lin, Z., Chambers, J.C., Bekker-Jensen, S., Meunier, E.*, and Zhong, F.* (2024). Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome. Proc Natl Acad Sci U S A e2309579121. 10.1073/pnas.2309579121.
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Balasubramaniam, K., He, T., Chen, H., Lin, Z., and He, C.Y.* (2024). Cytoplasmic preassembly of the flagellar outer dynein arm complex in Trypanosoma brucei. Mol Biol Cell. 10.1091/mbc.E24-06-0263.
2023
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Chuah, Y.H., Tay, E.X.Y., Grinchuk, O.V., Yoon, J., Feng, J., Kannan, S., Robert, M., Jakhar, R., Liang, Y., Lee, B.W.L., Wang, L.C., Lim, Y.T., Zhao, T., Sobota, R.M., Lu, G., Low, B.C., Crasta, K.C., Verma, C.S., Lin, Z., and Ong, D.S.T.* (2023). CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma. Cell Death Differ. 10.1038/s41418-023-01192-3.
Supervised Research
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Zhang, Y., Lin, Z., Zhu, J., Wang, M., and Lin, H.* (2021). Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway. Proc Natl Acad Sci U S A 10.1073/pnas.2104577118.
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Juszkiewicz, S., Slodkowicz, G., Lin, Z., Freire-Pritchett, P., Peak-Chew, S.Y., and Hegde, R.S.* (2020). Ribosome collisions trigger cis-acting feedback inhibition of translation initiation. Elife. 10.7554/eLife.60038.
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Lin, Z., Gasic, I., Chandrasekaran, V., Peters, N., Shao, S., Mitchison, T.J., and Hegde, R.S.* (2020). TTC5 mediates autoregulation of tubulin via mRNA degradation. Science 10.1126/science.aaz4352.
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Zhang, Y., Lin, Z., Wang, M., and Lin, H.* (2018). Selective Usage of Isozymes for Stress Response. ACS Chem Biol. 10.1021/acschembio.8b00767.
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Juszkiewicz, S., Chandrasekaran, V., Lin, Z., Kraatz, S., Ramakrishnan, V., and Hegde, R.S.* (2018). ZNF598 Is a Quality Control Sensor of Collided Ribosomes. Mol Cell. 10.1016/j.molcel.2018.08.037.
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​Lin, Z., Dong, M., Zhang, Y., Lee, E.A., and Lin, H.* (2016). Cbr1 is a Dph3 reductase required for the tRNA wobble uridine modification. Nat Chem Biol 10.1038/nchembio.2190.
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Lin, Z., Su, X., Chen, W., Ci, B., Zhang, S., and Lin, H.* (2014). Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis. J Am Chem Soc. 10.1021/ja5009272.
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Su, X., Lin, Z., and Lin, H.* (2013). The biosynthesis and biological function of diphthamide. Crit Rev Biochem Mol Biol. 10.3109/10409238.2013.831023.
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Su, X., Lin, Z., Chen, W., Jiang, H., Zhang, S., and Lin, H.* (2012). Chemogenomic approach identified yeast YLR143W as diphthamide synthetase. Proc Natl Acad Sci U S A. 10.1073/pnas.1214346109.
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Lin, Z., Yu, D., Sum, Y.N., and Zhang, Y.* (2012). Synthesis of functional acetylene derivatives from calcium carbide. ChemSusChem. 10.1002/cssc.201100649.
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Lin, Z., Yu, D., and Zhang, Y.* (2011). Propargylic amines constructed via copper-catalyzed three-component coupling of terminal alkynes, benzal halides and amines. Tetrahedron Lett. 10.1016/j.tetlet.2011.07.099